Weekly Digests



Cancer immunity — can it stem from stem cells?

March 14, 2018

Induced pluripotent stem cells (iPSCs), lineage-specific adult cells that are reprogrammed to an earlier pluripotent state, bypass the ethical controversy associated with embryonic stem cell use. Because iPSCs and cancer cells overlap in the expression of many tumor-associated genes, iPSCs can prime the immune system for both known and potentially unknown tumor-associated antigens...

TGFβ spells trouble for cancer immunotherapy response

March 7, 2018

Trying to figure out why some patients respond to immune checkpoint blockade while others do not may sometimes feel as hopeless as repeatedly hitting one’s head against a brick wall. However, the latest research by Mariathasan et al. and Tauriello et al., published in Nature, may tone down the headache. While the two...